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Research at McLean: Fueling Discovery, Advancing Care

Throughout its 200-year history, McLean Hospital has been defined by research excellence, marked by a long list of “firsts” in innovation and discovery. In 1888, McLean became the first psychiatric hospital in the United States to establish basic and clinical laboratories to study the biological...

Technology: A Fruitful Frontier

In 2016, McLean Hospital established the Institute for Technology in Psychiatry (ITP), becoming one of the first institutions of its kind to make a major investment in digital health care and research. Leveraging academic and industry partners, along with patients willing to evaluate technology...

Celebrating a New Era in Psychiatric Research

“It’s an honor and a responsibility to live up to the traditions of everyone whose work and dreams have been supported by the Rappaport Foundation in the fields of medical research, the arts, and public policy,” said Bill Carlezon, PhD, chief of McLean’s Rappaport Center of Excellence in Basic...

Feelings of Detachment Predict Worse Mental Health Outcomes After Trauma

Results from the largest prospective study of its kind indicate that for individuals who experience trauma, the presence of dissociation—a profound feeling of detachment from one’s sense of self or surroundings—may indicate a high risk of later developing severe post-traumatic stress, depression...

McLean Hospital and GrayMatters Health Awarded a BIRD Foundation Grant

GrayMatters Health, a digital therapeutics start-up company, announced that the BIRD Israel-U.S. Binational Industrial Research and Development Foundation awarded a grant to McLean Hospital and the company to develop a novel solution for the therapy of major depressive disorder (MDD) with anhedonia...

McLean Hospital Joins Partnership to Research Generational Trauma

McLean Hospital has partnered with the nonprofit arm of The Connor Group, a real estate investment firm, as well as the University of Dayton and Dayton Children’s Hospital, on a groundbreaking research project aimed at understanding the biological link between childhood hardships and mental...

New Study Uncovers Details Behind the Body’s Response to Stress

The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood. New research now details the interplay between proteins involved in controlling the body’s stress response and points to...

McLean Researchers Elected to 2022 ACNP Leadership Roles

Kerry J. Ressler, MD, PhD, has been elected as the next president-elect of the American College of Neuropsychopharmacology (ACNP), and Bill Carlezon, PhD, has been elected as an ACNP council member. Ressler and Carlezon will commence their new ACNP roles in 2022. Founded in 1961, the ACNP is an...

Identifying the Roots of PTSD

Survival. In an animal kingdom enriched by a diversity of species, it is the one trait shared by organisms as simple as worms and as complex as humans. And the proof is in a protein with the hopelessly complex name of pituitary adenylate cyclase-activating polypeptide. Commonly referred to by...

Advancing the Understanding of PTSD

Perhaps one of the most misused words in modern society, “trauma” is used in daily language to describe all sorts of unpleasant or uncomfortable situations. But for 5-10% of the population, trauma and the accompanying post-traumatic stress disorder (PTSD) is a very precise condition with very real...

New Collaboration Seeks to Understand Trauma’s Impact on Genes

Why does one person who experienced severe childhood adversity become homeless or addicted, while another with a similar background builds a loving family life and a thriving career? Is the answer in our genes, or perhaps in how trauma affects our genes? A collaboration between McLean Hospital and...

Gift Propels Trauma Research, Care, and Training to New Levels

McLean is home to a number of prominent clinicians who provide some of the country’s most specialized care for individuals struggling with complex post-traumatic stress disorder (PTSD). Its researchers are leading the scientific front by exploring the environmental, genetic, and neurobiological...