Content Related to Depression

Video: What Is Electroconvulsive Therapy (ECT) and How Does It Work?

Electroconvulsive therapy, or ECT, is a highly effective treatment for mental health conditions like major depression, mania, catatonia, and schizophrenia. It can be especially helpful to those who have not found relief with other treatments. Learn more about ECT, how it works, and what you might...

The Silent Strain at the Top: Mental Health Among Executive Leadership

Executive leadership often conjures images of success—corner offices, global influence, and the power to shape industries. But behind the glossy titles and impressive resumes, many leaders quietly struggle with the crushing weight of responsibility. The reality? Executive burnout, chronic stress...

Video: What Is Ketamine Therapy and How Does It Work?

Ketamine treatment can be an effective strategy for patients struggling with depression. McLean Hospital provides both intravenous ketamine and FDA-approved intranasal esketamine, or Spravato, to qualifying patients. Learn more about ketamine therapy, how it works, and what you might expect at a...

Study Finds Ketamine Therapy Can Reduce Symptoms in Patients With Treatment-Resistant Depression

A new study led by Mass General Brigham investigators compared the effects of repeated intravenous (IV) ketamine and intranasal (IN) esketamine in patients with treatment-resistant depression. In a retrospective analysis of data from a cohort of 153 adult patients treated at McLean Hospital, a...

McLean Hospital’s TMS Program Expands Access to Mental Health Treatment

Transcranial magnetic stimulation (TMS) is quickly becoming an important treatment option for severe, treatment-resistant depression and other mental health disorders. McLean Hospital’s accelerated TMS program makes it more accessible for patients who have restricted schedules. Under the leadership...

Researchers Unveil Shared and Unique Brain Molecular Dysregulations in PTSD and Depression

A comprehensive approach that examines the intersection of multiple biological processes is necessary to elucidate the development of stress-related disorders. In a new study, investigators from McLean Hospital, a member of the Mass General Brigham health care system, working with colleagues at The...

Novel Service for Treatment-Resistant Depression Launches at McLean Hospital

With a commitment to caring for individuals with complex behavioral and mental health conditions, McLean Hospital recently launched an accelerated transcranial magnetic stimulation (TMS) program that reduces the amount of time it takes for individuals to feel relief from depression. Typically used...

Video: What Is Transcranial Magnetic Stimulation (TMS) and How Does It Work?

Transcranial magnetic stimulation is a safe and effective treatment proven to help those who struggle with severe depression. It is particularly helpful for people with depression who have not experienced significant relief from antidepressant medications or have difficulty with side effects. Learn...

Wellcome Leap Trial Aims To Improve Depression Care Through Precision Medicine

Depression has become the leading cause of disability worldwide across all illnesses, according to the World Health Organization. In only a single year, 264 million people deal with depression, and 800,000 lives are lost to suicide. Yet psychiatrists are often forced to resort to a trial-and-error...

Video: Lecture – Uncovering Mechanisms To Improve TMS Effectiveness

Presented by Joshua C. Brown, MD, PhD, McLean Hospital – McLean Forum lecture Transcranial magnetic stimulation (TMS) is a safe and effective tool for treatment-resistant depression and obsessive compulsive disorder and has the potential to treat any brain disorder involving cortical networks. This...

Video: Lecture – Pediatric Depression: Evidence-Based and Emerging Treatments, Including Ketamine

Presented by Michael Bloch, MD, MS, Child Study Center – Nancy Black Simches Visiting Scholar Series lecture

Single-Cell Study Reveals Genes That May Be Involved in Post-Traumatic Stress and Major Depressive Disorders

An international team led by investigators at McLean Hospital analyzed the genes expressed in approximately 575,000 individual cells from the brains of people with and without post-traumatic stress and major depressive disorders (PTSD and MDD), revealing new insights into the mechanisms behind the...

Neurotherapeutics Clinic Opens at McLean SouthEast in Middleborough

In an effort to deliver cutting-edge therapies to patients with major depression with convenient access to their local communities, McLean Hospital is expanding its treatment services with the opening of a neurotherapeutics clinic at the McLean SouthEast campus at 52 Oak Street in Middleborough...

McLean Study Reveals No Beneficial Effect of Antidepressants Against COVID-19

Since the onset of the pandemic, scientists have been searching for existing, available medications that might be repurposed to treat COVID-19. Laboratory studies and observations in patients suggested that medications used to treat depression—especially so-called serotonergic antidepressants such...

McLean Hospital and GrayMatters Health Awarded a BIRD Foundation Grant

GrayMatters Health, a digital therapeutics start-up company, announced that the BIRD Israel-U.S. Binational Industrial Research and Development Foundation awarded a grant to McLean Hospital and the company to develop a novel solution for the therapy of major depressive disorder (MDD) with anhedonia...

Conte Center Grant Expands Studies of Brain Mechanisms Behind Depression and Anxiety

With a $15,973,571, five-year grant from the National Institute of Mental Health (NIMH), investigators from McLean Hospital and four other institutions will further their studies into the brain mechanisms behind depression and anxiety. Under the title “Novel Treatment Targets for Affective Disorders...

Christian A. Webb, PhD, Receives Anne Marie Albano Award From ABCT

Christian A. Webb, PhD, received the 2021 Anne Marie Albano Early Career Award for Excellence in the Integration of Science and Practice from the Association for Behavioral and Cognitive Therapies (ABCT). Webb, who is the director of McLean’s Treatment and Etiology of Depression in Youth (TEDY)...

Video: Lecture – Examining the Active Ingredients of Depression Treatment for Adolescents

Presented by Christian A. Webb, PhD, McLean Hospital – McLean Forum lecture Psychotherapies, including cognitive behavior therapy (CBT), have been shown to be effective at improving depressive symptoms in adolescents. However, the mechanisms through which depressed teens improve—and why many do not...

Study Examines the Cost-Effectiveness of Esketamine

A paper authored by researchers from McLean Hospital examines the feasibility of esketamine, a nasal spray to treat severe depression. Titled “Cost-Effectiveness of Esketamine Nasal Spray for Patients With Treatment-Resistant Depression in the United States,” the paper was published on July 7 in...

Philanthropy Bolsters Research Into Teen Depression

How do you predict which teenagers will develop clinical depression? Can you use brain activity, mood or behavior patterns, and other information? Are there targeted prevention strategies that could stop a vulnerable young person from plunging into depression? And for teenagers who are currently...

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