Content Related to Basic Neuroscience

Research at McLean: Fueling Discovery, Advancing Care

Throughout its 200-year history, McLean Hospital has been defined by research excellence, marked by a long list of “firsts” in innovation and discovery. In 1888, McLean became the first psychiatric hospital in the United States to establish basic and clinical laboratories to study the biological...

A Surprising Discovery Will Transform Our Understanding of Huntington’s Disease

Scientists at McLean Hospital, the Broad Institute of MIT and Harvard, and Harvard Medical School have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington’s disease leads to the death of brain cells. The findings change the understanding of the fatal...

Celebrating a New Era in Psychiatric Research

“It’s an honor and a responsibility to live up to the traditions of everyone whose work and dreams have been supported by the Rappaport Foundation in the fields of medical research, the arts, and public policy,” said Bill Carlezon, PhD, chief of McLean’s Rappaport Center of Excellence in Basic...

Video: Lecture – The Alfred Pope Award for Early Career Investigators 2023

Honoring Andrea M. Cataldo, PhD, and Antonia V. Seligowski, PhD, McLean Hospital – The Alfred Pope Award for Early Career Investigators Each year, McLean Hospital recognizes young researchers with the Alfred Pope Award for Early Career Investigators. The honor is named for one of the hospital’s most...

Rappaport Gift Is Culmination of Two Decades of Basic Neuroscience Support

Phyllis and Jerry Rappaport have always taken two things very seriously: McLean Hospital’s leadership in neuroscience research and the importance of emerging leaders in advancing the field of psychiatry. As evidence, and as a capstone to a 20-year relationship with the hospital, the couple has...

Nathaniel G. Harnett, PhD, Receives PFDI Faculty Fellowship

McLean Hospital’s Nathaniel G. Harnett, PhD, is the recipient of the 2022 Harvard Catalyst Program for Diversity Inclusion (PFDI) Faculty Fellowship. Harnett is an assistant neuroscientist at McLean and an assistant professor of psychiatry at Harvard Medical School. The PFDI program is a two-year...

Video: Lecture – The Alfred Pope Award for Early Career Investigators 2022

Honoring Nicole M. Benson, MD, and Jakob Hartmann, PhD, McLean Hospital – The Alfred Pope Award for Early Career Investigators Each year, McLean Hospital recognizes young researchers with the Alfred Pope Award for Early Career Investigators. The honor is named for one of the hospital’s most...

McLean Researcher Nikolaos Daskalakis Awarded International Life Science Grant

Nikolaos P. Daskalakis, MD, PhD, director of the Neurogenomics and Translational Bioinformatics Laboratory at McLean Hospital, is part of an international research collaboration that has been awarded a $1.14 million grant from the prestigious Human Frontier Science Program (HFSP). Highlights An...

Investigators at McLean Receive Award To Test Xenon Gas as Treatment for Opioid Use Disorder

Researchers at McLean Hospital, in collaboration with Nobilis Therapeutics, have been awarded a grant to test a novel xenon gas-based treatment for opioid use disorder. Highlights McLean Hospital researchers have been awarded a grant by the National Institute on Drug Abuse to test xenon gas to...

New Summer Research Program Welcomes Undergraduates of Color

“Racial and ethnic diversity in science is essential to delivering excellence and superior innovations,” said Stephanie Pinder-Amaker, PhD, McLean’s chief diversity, equity, and inclusion officer. McLean President and Psychiatrist in Chief Scott L. Rauch, MD, Pinder-Amaker, and other members of...

New Study Uncovers Details Behind the Body’s Response to Stress

The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood. New research now details the interplay between proteins involved in controlling the body’s stress response and points to...

McLean Researchers Elected to 2022 ACNP Leadership Roles

Kerry J. Ressler, MD, PhD, has been elected as the next president-elect of the American College of Neuropsychopharmacology (ACNP), and Bill Carlezon, PhD, has been elected as an ACNP council member. Ressler and Carlezon will commence their new ACNP roles in 2022. Founded in 1961, the ACNP is an...

Video: Lecture – The Alfred Pope Award for Early Career Investigators 2021

Honoring Nathaniel G. Harnett, PhD, and Lauren A.M. Lebois, PhD, McLean Hospital – The Alfred Pope Award for Early Career Investigators Each year, McLean Hospital recognizes young researchers with the Alfred Pope Award for Early Career Investigators. The honor is named for one of the hospital’s most...

Video: Lecture – Translational Studies of Inflammatory Factors in Autism

Presented by Bill Carlezon, PhD, McLean Hospital, and Christopher J. McDougle, MD, Massachusetts General Hospital – Crossroads in Psychiatry lecture In this talk, McDougle and Carlezon discuss past and present investigations into the causes of autism spectrum disorder (ASD). They present information...

Video: Lecture – Autologous iPSC-Based Cell Therapy for Parkinson’s Disease

Presented by Penny Hallett, PhD, McLean Hospital – McLean Forum lecture Parkinson’s disease (PD), is characterized by tremor, bradykinesia (slowness of movement), rigidity, and postural instability. At the time of diagnosis, about 60% of the midbrain dopamine (mDA) neurons have already degenerated...

Reflecting on a Brilliant Career in Neuropsychiatry

Joseph T. Coyle, MD, director, Laboratory for Psychiatric and Molecular Neuroscience, one of the most renowned psychiatric neuroscientists in history, transitioned to emeritus status on October 30. Coyle’s groundbreaking research has illuminated some of the neurological mechanisms underlying...

Neuron-Based Gene Expression Study Reveals Insights on Fear and Its Regulation

Fear and fear extinction learning (the gradual reduction of fear by repeated exposure to the feared object) are adaptive processes caused by molecular changes in specific brain circuits, and they’re perturbed in conditions such as anxiety and post-traumatic stress disorder. A new study by...

New Study May Reveal Link to Lipids Playing a Key Role in Parkinson’s Disease

In a novel research study conducted by a team from the Neuroregeneration Institute at McLean Hospital, investigators believe they have found key brain cell type changes involving lipids, inflammation, and the development of Parkinson’s disease (PD). Their findings appear in the current issue of the...

Personalizing Stem Cell Therapy for Parkinson’s Disease

In the United States alone, as many as one million people have Parkinson’s disease (PD), with approximately 60,000 cases being diagnosed each year, according to the Parkinson’s Disease Foundation. Kwang-Soo Kim, PhD, director of the Molecular Neurobiology Laboratory at McLean Hospital and professor...

Expression of Certain Genes May Affect Vulnerability to Post-Traumatic Stress Disorder

Results from a new study suggest that whether certain genes are expressed—turned on or off—may play a role in susceptibility to post-traumatic stress disorder (PTSD). The study, which was conducted by an international team led by investigators at McLean Hospital and appears in the journal Cell...

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